The show centered around Samantha Newly (Christina Applegate), a 30-year-old vice president of a real estate firm who develops retrograde amnesia after a hit and run accident. After awakening, she progressively realizes to her dismay that she had been selfish and unlikeable before her accident, and therefore sets out to make amends and become a better daughter to her somewhat dysfunctional parents, Howard (Kevin Dunn) and Regina (Jean Smart), a better friend to self-centered Andrea (Jennifer Esposito), and needy but well-meaning Dena (Melissa McCarthy), and a better on-again, off-again girlfriend to her roommate and ex-boyfriend, Todd (Barry Watson). Wryly observing her transformation from "Old Sam" to "New Sam" is Samantha's bemused doorman, Frank (Tim Russ of Star Trek Voyager fame).
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